Why Do Dermatologists Recommend Niacinamide for Skin?

Dermatologists have been advocating the use of Niacinamide as one of the few recognised important elements for general skin health. 

This well-known, tried-and-true component is increasingly appearing in formulas ranging from creams to serums. As a dermatology-inspired brand, we believe in the importance of this component in skincare. 

So I will go over everything from what this skincare ingredient is to what it can do to improve your skin—and why dermatologists at Rodan and Fields skincare are excited about it.

What is Niacinamide?

Niacinamide is a vitamin B3 compound derived from vitamin B3 (niacin). A beta-hydroxy beta-carotene derivative with the chemical structure C6H6N3O4. 

It Does Derive from niacin, the active form of vitamin B3; Niacinamide is a group of compounds called retinoids. A single chemical is actually combined with four different amino acids to create the compound. Retinoids can help reduce redness and inflammation. 

The active form of vitamin B3, Niacinamide, is used in skincare formulations for hyperpigmentation, anti-ageing and acne treatments.

Is this niacin?

Despite its name, Niacinamide is not the same as niacin. Instead, they're two sorts of B-3.

However, Niacinamide can be made from niacin tablets. This occurs when the body has too much niacin. The body can also make Niacinamide from tryptophan. Always be with your doctor before taking B-3 or other supplements.

The distinction between topical (skincare) and dietary (supplements, food) nicotinamide.

Niacinamide For Skin Blog Post

Dietary sources of vitamin B3 include fish and eggs. But these dietary elements have little effect on skin health. So instead, use Niacinamide topically to ensure it targets your skin conditions. Skincare rescue.

Rodan and Fields Dr Sumita Butani, SVP, Innovation - Dr Butani advises an anti-inflammatory diet. "All those sugars we love are bad." Dr Butani recommends a low-carbohydrate, low-sugar diet to age healthily. 

Helping fight ageing and inflammation. "It makes sense to make a major effort with food and exercise," Dr Sumita says. 

"Too much activity can cause inflammation and breakdown, yet good exercise strengthens mitochondria." Stronger mitochondria optimise enzymatic reactions within the cell.

What is Niacinamide's benefits for our skin?

The antioxidant properties of niacinamide help protect the skin from environmental damage.

Among the skin benefits of using Niacinamide are:

  • Immunity. Niacinamide helps form keratin, a protein that maintains skin tight and healthy.
  • Lipid wall Niacinamide can help your skin develop a ceramide (lipid) barrier, which helps retain moisture. This is great for eczema and older skin.
  • REDNESS SKIN PEOPLE True Source niacinamide decreases inflammation, which may help reduce the redness of eczema and acne.
  • Reduces pore size. Smooth and hydrated skin Trusted Source may also help reduce pore size naturally over time.
  • Rules oil. Moisture retention isn't just for dry skin. Niacinamide can also help manage the quantity of oil produced by the sebaceous glands, preventing overproduction.
  • Prevents sun damage. Niacinamide can both rebuild healthy skin cells and protect them from UV damage.
  • Hyperpigmentation treatment 5 per cent niacinamide has been shown to help brighten dark spots in some studies, after four weeks, but not for two months. Increased collagen production may be the cause.
  • Retains elasticity. The same concentration was found to help reduce some indications of solar damage associated with ageing. The fine lines and creases.
  • Combats oxidative stress. Niacinamide protects skin cells from environmental challenges such as sunlight, pollution, and pollutants.
  • Helps acne. Niacinamide may improve inflammatory acne such papules and pustules. Lesions may fade, and skin texture may improve.

How much Niacinamide is effective in skin care products?

Niacinamide For Skin Blog Post AAW

Not all active ingredient percentages are created equal. For example, Niacinamide is effective at 2% doses. Topical niacinamide studies utilise 2-10%. (not orally ingested tablets). Some formulations contain 20% niacinamide, which is excellent for more advanced signs of damage. If you're sensitive, start low. 2% is advised.

How to Pick the Right Niacinamide Skincare Products for your skin

It should say the percentage on the label or ingredients list. This indicates its potency and, if you have sensitive skin, its potential irritation. Begin with a 2%-5% serum.

  • Skincare Ingredient quality 

While Niacinamide is a multitasker in itself, it never hurts to have extra benefits. In a single step, I like a product that has multiple active ingredients in high concentrations. This simplifies my routine. Always look for good ingredients.

  • Skincare Formulation

Even if a serum works, I won't use it if it's unpleasant to use. I like cheap niacinamide serums, although they don't always have a nice recipe. I prefer a product that absorbs and dries quickly so I can move on.

Are There Any Side Effects to Using Niacinamide Topically?

The most commonly reported side effect is dryness or irritation at the site of application. 

Also, depending on how long you've been using the product and how intensely you apply it, skin reactions may be visible in weeks, months, or even years. 

Which is more effective in skincare: niacinamides or vitamin C? Which specific skin conditions do they best address?

Niacinamide For Skin Blog Post

According to Dr Butani SVP at Rodan and Fields, neither is superior to the other. Rodan and Fields Multi-Med Therapy approach to men's and womens' skin issues is the right answer. However, Dr Butani also says you can't rely on one molecule to be the miracle that saves you from a condition. 

So, it is the best molecule in an active formula that really goes to its target, which causes change. If you have Vitamin C but has been neutralised (the formula has become brown, oxidised, dead, and no longer active), it will not perform efficiently. 

Same thing if you have Vitamin C in a recipe with an incorrect pH. There is no longer an active molecule.

"When we get into the hard science, when we say Multi-Med Therapy, it's optimising each molecule with the optimum pH with the correct formulations that are truly active in doing the heavy lifting," Dr Butani explains. 

"And, once again, we do not believe it is only Vitamin C or that Vitamin C is superior to Niacinamide because why not have both when they can both provide benefits?"

How do Know if my skin should be using Niacinamide? 

  • Niacinamide for Hyperpigmentation

It increases keratin and ceramide levels in the skin. This improves skin moisture retention, keeping dry skin healthy, firm, and hydrated. This is vital for mature skin.

Niacinamide, found in moistened skin, regulates sebaceous gland oil production. So it reduces skin moisture loss and gland overheating.

Resulting in your skins ability to regenerate cells, defend itself from harmful UV rays, and naturally reverse sun-induced skin damage like wrinkles and fine lines.

The 'maverick' component is antimicrobial and reduces skin inflammation and redness. It treats skin irritation, acne, blotchiness, eczema, and other inflammatory skin conditions. When applied regularly, it promotes collagen formation, cures hyperpigmentation, and naturally minimises skin pores.

  • Niacinamide for Anti-ageing

Niacinamide has been proven to decrease transepidermal water loss by improving stratum corneum barrier function. Furthermore, Niacinamide stimulates the skin's natural lipid production, particularly ceramides.

Rodan and Fields REVERSE TARGETED DARK SPOT CORRECTOR - with Niacinamide for Anti-ageing

Attempt to remove obstinate dark marks. For clearer, more even-toned skin, the exclusive RF3 Antioxidant Complex precisely targets and reduces the size + intensity of discolouration + dark spots. It's the ideal complement to any Regimen.

Typical Usage: Twice daily, in the morning and evening.

PRIMARY BENEFITS: Reduces dark spots visibly and protects against environmental aggressors that cause discolouration

SKIN CONCERNS: Unwanted dark spots and blotches, uneven skin tone

  • Niacinamide for Acne-prone skin?

The antibacterial characteristics of niacinamide help treat inflammatory acne caused by propionibacterium acnes (p.acnes) in clogged pores.

Niacinamide is a gentle exfoliant and sebum reducer. For non-inflammatory acne like blackheads and whiteheads, it can help reduce excess oil production and improve the skin's capacity to shed dead cells.

Hormones, stress, or specific dietary habits may cause acne. However, it may help reduce the appearance of breakouts and reduce redness and swelling.

Niacinamide Benefits for Acne 

Niacinamide is well-known as an acne treatment. It works in several ways:

  • Sebum reduction: Sebum is produced by the sebaceous glands in your skin. Niacinamide is sebostatic, meaning it lowers sebum secretion. This is vital because excess sebum and dead skin cells get caught in your pores, causing inflammatory and non-inflammatory acne. As a result of lowering sebum production, Niacinamide lessens the likelihood of acne worsening or even occurring.
  • Anti-inflammatory effects of niacinamide help minimise acne redness and oedema. It does this by inhibiting enzymes involved in the expression of inflammation-promoting genes. As a result, Niacinamide for acne can help reduce the appearance of outbreaks.
  • Accelerating cell turnover rate: The skin's failure to adequately shed dead cells adds to acne development. Although not established, Niacinamide may help enhance skin surface cell turnover, minimising the probability of dead skin cells getting trapped in pores.

Rodan and Fields Skincare with Niacinimide - FOR ACNE


Wash away your blemishes. Clear blemishes and unclog pores while nourishing skin for cleaner, brighter-looking skin.

Typical Use: Twice daily, in the morning and evening.

Primary benefits: Removes excess oil, makeup, and pollutants that create clogged pores and inflammation.

SKIN CONCERNS: Adult acne and pimples, oiliness, uneven tone and texture


Allow your pores to breathe. This toner contains gentle Alpha-Hydroxy Acids that help open and unclog pores while also brightening, relaxing, and firming the skin.

Typical Dosage: 1-2 times per day KEY BENEFITS: Exfoliates, soothes, and calms acne-prone skin while also clearing pores and brightening tone.

SKIN CONCERNS: Adult acne and pimples, oiliness, uneven tone and texture Pores that are clogged and swollen, Blackheads


Give acne a one-two punch. This dual-chamber technology penetrates your pores with 2.5 per cent Benzoyl Peroxide to help remove and prevent blemishes while moisturising and noticeably plumping skin.

Typical use: 1-2 times a day is a typical dose.

KEY BENEFITS: Clears acne and prevents outbreaks by penetrating clogged pores, hydrating, and visibly firming skin.

CONCERNS ABOUT THE SKIN: Adult acne and pimples, Oiliness, Inconsistent tone and texture, Pores that are clogged and swollen, Blackheads

How to use Niacinamide for Anti-ageing

What is the function of niacinamides? Why are they in the new and enhanced REDEFINE Regimen?

Dr Sumita Butani, SVP of Innovation at Rodan + Fields, was consulted in this case. They point out that Niacinamide has been used for a long time, both as an oral supplement and as a topical agent in all aspects of skincare, particularly because it is anti-inflammatory. That is, it reduces oedema, redness, and inflammation. 

Skin ageing is caused by inflammation. "So, everything we can do to stimulate anti-inflammatory in the body throughout its natural breakdown system is beneficial," adds Dr Butani. Niacinamide addresses this critical area of inflammation. 

By reducing inflammation, you can prevent oxidants (the reason we ingest and apply antioxidants) from being released by restricting the harmful oxidant molecules. You also have less Peptide breakdown and less collagen damage in the skin itself. Niacinamide also has skin lightening properties. "It's beneficial for acne, rosacea, and inflammation, making it beneficial for anti-ageing overall," she explains. "When we talk about delaying ageing, we are talking about the whole picture."

Rodan and Fields Skincare with Niacinimide - Anti-ageing

REDEFINE  Pore Refining Toner

Improved + new! Tone it up! Our skin-softening toner minimises and unclogs pores, promotes natural cell turnover, polishes and gently exfoliates skin to prepare it for the ingredients in the next steps of your Regimen. All skin types are suitable.


Improved + new! Moisturise deeply with our thick night cream to revitalise the skin's surface and lessen the appearance of fine lines and deep wrinkles. Furthermore, it now noticeably lifts, firms, and sculpts to improve facial contours. All skin types are suitable, but normal-dry skin is prefered.


Improved + new! Our potent, lightweight nightly lotion visibly lifts, firms, and sculpts to improve facial contours and minimises the appearance of your skins fine lines and deep wrinkles. In addition, it leaves a delicate moisturising layer on the skin that lasts all night. This lotion is best for combination-oily skin, but all skin types can use it.


Rodan and Fields new and improved  2-in-1 lightweight daily moisturiser + sunscreen with Peptide Technology + Botanical Extract noticeably improves fine lines, deep wrinkles, firmness and absorbs fast to leave a subtle layer of moisture that lasts. Suitable for all skin types but works best on combination-oily skin.

Where does Niacinamide go in a skincare routine?

The Rodan and Fields Redefine skincare products with Naciniamide start with step 2. After using a cleanser using our Redefine Toner, both AM and PM.

The Redefine Triple Defense AM lotion will be used as Step 3. Then in your evening skincare routine, you would use Step 2 Redefine toner and either the


For the treatment of Acne - Rodan and Fields Unblemish Regimen with Niacinamide would be used in the cleanser, toner, and 2 part acne treatment two times a day.

Our Reverse Targeted Dark Spot Corrector is used after Redefine, Unblemish Regimen's cleanser, toner for hyperpigmentation treatment. Thus, adding your moisturiser after and sunscreen in the AM.

How Often to use Niacinamide

The optimal amount of Niacinamide is twice a day for anti-ageing. This is important because Niacinamide breaks down quickly, leaving behind the remaining niacin and choline. 

You should always apply sunscreen, moisturiser, and any other ingredients to your skin before using Niacinamide on it. Long-term use of Niacinamide is safe and has few side effects, but there are some signs and symptoms of long-term use. 

Key Takeaway's Niacinamide for skin

How long does it take for niacinamide-containing products to work?

Dr Butani emphasises the significance of formulation above a single substance. 

The key here, like with any skincare routine, is consistency. Using the entire REDEFINE Regimen, you should anticipate noticing the first visible benefits after 4 weeks, followed by a greater impact after 8 weeks. 

The clinical trials of the REDEFINE Regimen speak for themselves (please keep in mind that these results are from participants using the entire Regimen, as recommended).

  • 94 per cent of participants had smoother, more supple skin after 8 weeks. 
  • 94 per cent reported smoother skin, while 
  • 91 per cent reported firmer skin. In addition, 
  • *85% had a better overall appearance/healthy glow.

Bottom line: Niacinamide is a tried-and-true substance that plays a significant role in skincare. Vitamin B3 (Niacinamide) is contained in REDEFINE Pore Refining Toner, for example, and acts to dramatically evening out the appearance of skin tone for a youthful glow.

Using this toner in conjunction with the other steps of the Regimen assists in addressing all major indications of ageing. However, as you are aware, there are no "wonder" ingredients or products. Consistency is the key to your skincare routine, using the right ingredients in the right order.


Niacinamide: A B vitamin that improves ageing facial skin appearance

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Topical Niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in ageing facial skin1

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